Based on an ultramultiplex PCR approach, it enables efficient enrichment and library preparation for tens of thousands of targets through a two-step enzymatic reaction in a single tube. Leveraging superior PCR primer design and amplification chemistry, the technology delivers exceptional performance with trace samples (e.g., cfDNA, single cells, ancient DNA, FFPE) for high-sensitivity detection.

Custom Design Single site to multi-gene panels.
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Rapid Delivery Efficient production, fast turnaround.
Precision Targeting Multiplexed amplification with high-specificity primers.
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Broad Application Research, drug development & molecular diagnostics.
ATOPlex, a custom targeted sequencing panel platform, offers both ready-to-use and customized products. These panels are suitable for diverse sample types including blood, cell-free nucleic acids, FFPE samples, and environmental extracts. They are compatible with a wide range of automation equipment and support sequencing on both DNBSEQ™ and CycloneSEQ™ platforms. ATOPlex panels enable the precise detection of various mutations such as SNVs (Single Nucleotide Variants), Indels (Insertions/Deletions), STRs (Short Tandem Repeats), CNVs (Copy Number Variations), and Fusions, comprehensively meeting application requirements across agriculture, public health, environmental monitoring, food safety, and other fields.
Ready-to-Use Panels
Pre-configured targeted sequencing products for universal applications. Covers public health, environmental testing, agricultural breeding, and forensics.
Custom Panels
Tailored panel developed for your specific needs. Submit region of interest via . Production and delivery within 4 weeks upon agreement finalization.

标题图标 ATOPlex technology

Based on an ultramultiplex PCR approach, it enables efficient enrichment and library preparation for tens of thousands of targets through a two-step enzymatic reaction in a single tube. Leveraging superior PCR primer design and amplification chemistry, the technology delivers exceptional performance with trace samples (e.g., cfDNA, single cells, ancient DNA, FFPE) for high-sensitivity detection.

Auto-workflow Automated Design & Operation
  • Design automation
  • Process automation
Trace-detection Minimal Input with Crude Sample
  • Ultra-low sample requirement
  • Direct amplification
One-tube Single-tube Processing
  • Ultrahigh-plex in single tube
  • No tube changes
Pure-PCR Superior Contaminant Resistance
  • Inhibitor tolerance
  • Aerosol contamination prevention

标题图标 Amplification strategy

The ATOPlex technology employs a two-step PCR approach to achieve target region enrichment and sample barcoding.

ATOPlex 2-Step strategy

标题图标 Application case

ATOPlex employs ultra-multiplex PCR technology to achieve high-specificity enrichment with minimal dimer formation. The right figure demonstrates the enrichment performance of ATOPlex technology—designed with ultrashort amplicons (60-90 bp) targeting 2,009 high-frequency SNP loci (population frequency >0.3)—on trace nucleic acid samples. Results show excellent sequencing performance of ATOPlex libraries on the DNBSEQ platform.

标题图标 Total solution

MGI develops streamlined omics tools for life sciences, delivering simplicity, speed, and precision. Offering end-to-end targeted sequencing solutions—from sample prep and library construction to high-throughput sequencing and bioinformatic analysis—tailored for your laboratory.